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Leucolysin

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Leucolysin
Identifiers
EC no.3.4.24.6
CAS no.72561-03-6
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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Leucolysin (EC 3.4.24.6, Leucostoma neutral proteinase, Leucostoma peptidase A) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of Phe1-Val, His5-Leu, Ala14-Leu, Gly20-Glu, Gly23-Phe and Phe24-Phe bonds in insulin B chain as well as N-blocked dipeptides

This enzyme is isolated from the venom of the western cottonmouth moccasin snake (Agkistrodon piscivorus leucostoma).

References

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  1. ^ Wagner FW, Spiekerman AM, Prescott JM (September 1968). "Leucostoma peptidase A. Isolation and physical properties". The Journal of Biological Chemistry. 243 (17): 4486–93. PMID 5684005.
  2. ^ Spiekerman AM, Fredericks KK, Wagner FW, Prescott JM (February 1973). "Leucostoma peptidase A: a metalloprotease from snake venom". Biochimica et Biophysica Acta (BBA) - Enzymology. 293 (2): 464–75. doi:10.1016/0005-2744(73)90353-7. PMID 4711816.
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