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L-peptidase

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L-peptidase
Identifiers
EC no.3.4.22.46
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

L-peptidase (EC 3.4.22.46) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-Gly bond. Subsequently, it cleaves host cell initiation factor eIF-4G at bonds -Gly-Arg- and -Lys-Arg-

This enzyme is coded bz foot-and-mouth disease virus.

References

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  1. ^ Piccone ME, Zellner M, Kumosinski TF, Mason PW, Grubman MJ (August 1995). "Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus". Journal of Virology. 69 (8): 4950–6. PMC 189310. PMID 7609064.
  2. ^ Guarné A, Hampoelz B, Glaser W, Carpena X, Tormo J, Fita I, Skern T (October 2000). "Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes". Journal of Molecular Biology. 302 (5): 1227–40. doi:10.1006/jmbi.2000.4115. hdl:10261/111148. PMID 11183785.
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