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HIST1H2AA

From Wikipedia, the free encyclopedia
H2AC1
Identifiers
AliasesH2AC1, H2AA, H2AFR, bA317E16.2, TH2A, histone cluster 1, H2aa, histone cluster 1 H2A family member a, HIST1H2AA, H2A clustered histone 1, HISTH2AA
External IDsOMIM: 613499; MGI: 2448297; HomoloGene: 108269; GeneCards: H2AC1; OMA:H2AC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170745

NM_178183

RefSeq (protein)

NP_734466

NP_835490

Location (UCSC)Chr 6: 25.73 – 25.73 MbChr 13: 21.94 – 21.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2A type 1-A is a protein that in humans is encoded by the HIST1H2AA gene.[5][6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164508Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063021Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. ^ a b "Entrez Gene: HIST1H2AA histone cluster 1, H2aa".

Further reading

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