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GCLM

From Wikipedia, the free encyclopedia
GCLM
Identifiers
AliasesGCLM, GLCLR, glutamate-cysteine ligase modifier subunit
External IDsOMIM: 601176; MGI: 104995; HomoloGene: 1557; GeneCards: GCLM; OMA:GCLM - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308253
NM_002061

NM_008129

RefSeq (protein)

NP_001295182
NP_002052

NP_032155

Location (UCSC)Chr 1: 93.89 – 93.91 MbChr 3: 122.04 – 122.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene.[5][6]

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000023909Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028124Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gipp JJ, Bailey HH, Mulcahy RT (Feb 1995). "Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues". Biochem Biophys Res Commun. 206 (2): 584–9. doi:10.1006/bbrc.1995.1083. PMID 7826375.
  6. ^ a b "Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit".

Further reading

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