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Dimethylglycine oxidase

From Wikipedia, the free encyclopedia
dimethylglycine oxidase
Identifiers
EC no.1.5.3.10
CAS no.74870-79-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a dimethylglycine oxidase (EC 1.5.3.10) is an enzyme that catalyzes the chemical reaction

N,N-dimethylglycine + H2O + O2 sarcosine + formaldehyde + H2O2

The 3 substrates of this enzyme are N,N-dimethylglycine, H2O, and O2, whereas its 3 products are sarcosine, formaldehyde, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N,N-dimethylglycine:oxygen oxidoreductase (demethylating). It employs one cofactor, FAD.

Structural studies

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As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1PJ5​, 1PJ6​, and 1PJ7​.

References

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  • Mori N, Kawakami B, Tani Y, Yamada H (1980). "Purification and properties of dimethylglycine oxidase from Cylindrocarpon didymum M-1". Agric. Biol. Chem. 44 (6): 1383–1389. doi:10.1271/bbb1961.44.1383.