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DHRS1

From Wikipedia, the free encyclopedia

DHRS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDHRS1, SDR19C1, dehydrogenase/reductase (SDR family) member 1, dehydrogenase/reductase 1
External IDsOMIM: 610410; MGI: 1196314; HomoloGene: 41696; GeneCards: DHRS1; OMA:DHRS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136050
NM_138452

NM_026819

RefSeq (protein)

NP_001129522
NP_612461

NP_081095

Location (UCSC)Chr 14: 24.29 – 24.3 MbChr 14: 55.98 – 55.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dehydrogenase/reductase SDR family member 1, also known as Short chain dehydrogenase/reductase family 19C member 1 is an enzyme that in humans is encoded by the DHRS1 gene located on chromosome 14.[5][6][7]


Structure

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The DHRS1 gene is located on the chromosome 14q21.3 region and contains 9 exons. It encodes a 314-amino-acid, 33-kDa protein that is thought to be located to the endoplasmic reticulum and the mitochondrial inner membrane inside the cell.

Function

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The DHRS1 protein is thought to have oxidoreductase activity based on sequence similarity and conserved catalytic sites with other short-chain oxidoreductase enzymes. The enzyme is found to be expressed in the fetal brain.[8]

Interactions

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The DHRS1 protein is thought to interact with the protein phospholipid scrambase 1 (PLSCR1).[9]

References

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  1. ^ a b c ENSG00000284868 GRCh38: Ensembl release 89: ENSG00000157379, ENSG00000284868Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002332Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, et al. (Aug 2002). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain". Mol Biol Rep. 28 (4): 193–8. doi:10.1023/A:1015722001960. PMID 12153138. S2CID 29552121.
  6. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  7. ^ "Entrez Gene: DHRS1 dehydrogenase/reductase (SDR family) member 1".
  8. ^ Wu Q, Xu M, Cheng C, Zhou Z, Huang Y, Zhao W, et al. (2001). "Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain". Mol. Biol. Rep. 28 (4): 193–8. doi:10.1023/A:1015722001960. PMID 12153138. S2CID 29552121.
  9. ^ "IntAct Portal".

Further reading

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