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DDX42

From Wikipedia, the free encyclopedia
DDX42
Identifiers
AliasesDDX42, DDX42P, RHELP, RNAHP, SF3B8, SF3b125, DEAD-box helicase 42
External IDsOMIM: 613369; MGI: 1919297; HomoloGene: 49137; GeneCards: DDX42; OMA:DDX42 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007372
NM_203499

NM_028074

RefSeq (protein)

NP_031398
NP_987095

NP_082350
NP_001348569
NP_001348571
NP_001348572
NP_001348573

Location (UCSC)Chr 17: 63.77 – 63.82 MbChr 11: 106.22 – 106.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene.[5][6]

Function

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This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.[6]

Interactions

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DDX42 has been shown to interact with SF3B1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198231Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020705Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Suk K, Kim S, Kim YH, Oh SH, Lee MK, Kim KW, Kim HD, Seo YS (Apr 2000). "Identification of a novel human member of the DEAD box protein family". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1501 (1): 63–9. doi:10.1016/S0925-4439(00)00010-7. PMID 10727850.
  6. ^ a b "Entrez Gene: DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42".
  7. ^ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". The EMBO Journal. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.

Further reading

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