Jump to content

File:Epigenetic consequences of nucleosome reassembly defects at stalled replication forks.png

Page contents not supported in other languages.
This is a file from the Wikimedia Commons
From Wikipedia, the free encyclopedia

Original file (2,700 × 2,100 pixels, file size: 1.41 MB, MIME type: image/png)

Summary

Description
English: (A) Reassembly of histone H3/H4 heterodimers at replication forks is mediated by the sequential actions of the chromatin assembly factors ASF1 and CAF1. New histones carry H4K5ac/H4K12ac predisposition marks, which are required for their nuclear import. ASF1 can bind both new and evicted histones, ensuring tightly controlled histone recycling and nucleosome reassembly; (B) Replication stress interferes with the restoration of epigenetic information at stalled forks. Fork arrest results in excessive histone eviction and accumulation of ASF1 loaded with both old and new histones. Fork restart triggers rapid nucleosome assembly, which can result in unbalanced incorporation of old and new histones. Replication stress also promotes the accumulation of the H3K9me1 pre-deposition mark, which may serve as a template for H3K9me3 and HP1-mediated heterochromatin formation. Finally, impaired HDAC function may affect the removal of pre-deposition acetyl-marks, causing epigenetic changes in post-replication chromatin. Together, these defects have the potential to either promote or inhibit the expression of nearby genes.[1]
Date
Source https://doi.org/10.3390/genes6030858
Author Simran Khurana, and Philipp Oberdoerffer

Licensing

w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  1. Template:CC-notice

Captions

Epigenetic consequences of nucleosome reassembly defects at stalled replication forks

Items portrayed in this file

depicts

11 September 2015

image/png

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current23:43, 24 May 2020Thumbnail for version as of 23:43, 24 May 20202,700 × 2,100 (1.41 MB)Rob HurtUploaded a work by Simran Khurana, and Philipp Oberdoerffer from https://doi.org/10.3390/genes6030858 with UploadWizard

The following page uses this file:

Metadata