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File:Adenocarcinoma of Pancreas, FNA (5558060087).jpg

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English: This is one of the better differentiated areas, showing a flat sheet with prominent honeycombing. The disorganization, nuclear overlapping, and lack of uniform nuclear spacing provides a clue that is this adenocarcinoma (as opposed to non-neoplastic duct epithelium). However, if all I had was a paucicellular specimen consisting of a few such sheets, I would likely back off and call it nothing higher than "suspicious" for adenocarcinoma. Fortunately from a diagnostic standpoint, all of the other clinical, radiographic, and cytological findings pointed overwhelmingly at a diagnosis of malignancy, which made this case more straighforward than it could have been with a meager specimen and inadequate clinical and radiographic information.

Pancreatic adenocarcinomas can be very well differentiated, a fact that raises the risk of both false-positive and false-negative diagnoses. It is important to secure a good specimen (which requires immediate assessment by a pathologist or cytotechnologist during the procedure), as well as accurate and complete clinical info. In most freestanding imaging centers, with no on-site pathology coverage, these aspects are often ignored. I strongly recommend that patients have radiographically-directed biopsies performed only in facilities with pathology coverage on site.

Pathological and histological images courtesy of Ed Uthman at flickr.
العربية: تُظهر الخزعة بالإبرة للسرطانة الغدية البنكرياسية المتمايزة ورقة مسطحة مع نخاريب بارزة، يوفر اختلال التنظيم وتداخل الأنوية ونقص التساوي في تباعد الأنوية دليلًا على كون العينة سرطانة غدية (على عكس ظهارة القناة اللاورمية).
Date
Source Adenocarcinoma of Pancreas, FNA
Author Ed Uthman from Houston, TX, USA

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This image, originally posted to Flickr, was reviewed on 11 December 2013 by the administrator or reviewer File Upload Bot (Magnus Manske), who confirmed that it was available on Flickr under the stated license on that date.

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24 March 2011

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current12:05, 11 December 2013Thumbnail for version as of 12:05, 11 December 20131,704 × 1,135 (925 KB)File Upload Bot (Magnus Manske)Transferred from Flickr by User:CFCF

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