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File:180-TALEffectors TALEN.png

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English: Space-filling drawing of an engineered TAL effector/nuclease bound to double-helical DNA. TALE proteins contain a series of alpha-helical hairpin domains, each of which binds an individual DNA base, so that the protein recognizes a long, very specific DNA sequence. This engineered construct attaches the specific FOK1 nuclease to one end of the TALE protein, and when two copies bind as a dimer the nuclease cleaves both strands of the DNA. Drawn by David Goodsell from PDB files 1FOK (nuclease/DNA) and 3UGM (TALE/DNA).
Date
Source RCSB PDB Molecule of the Month
Author David Goodsell

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December 2014

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