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Carbonic anhydrase III, muscle specific

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CA3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCA3, CAIII, Car3, carbonic anhydrase 3
External IDsOMIM: 114750; MGI: 88270; HomoloGene: 31298; GeneCards: CA3; OMA:CA3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005181

NM_007606

RefSeq (protein)

NP_005172

NP_031632

Location (UCSC)Chr 8: 85.37 – 85.45 MbChr 3: 14.93 – 14.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.[5]

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue-specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. CA3 is insufficient in muscles of Myasthenia Gravis patients.[6] A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. Autoantibodies to CA3 have been found to be significantly higher in patients with rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes.[7] The gene spans 10.3 kb and contains seven exons and six introns.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164879Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027559Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shima K, Tashiro K, Hibi N, Tsukada Y, Hirai H (Jun 1983). "Carbonic anhydrase-III immunohistochemical localization in human skeletal muscle". Acta Neuropathologica. 59 (3): 237–9. doi:10.1007/BF00703210. PMID 6221502. S2CID 523577.
  6. ^ Du AL, Ren HM, Lu CZ, Tu JL, Xu CF, Sun YA (Mar 2009). "Carbonic anhydrase III is insufficient in muscles of myasthenia gravis patients". Autoimmunity. 42 (3): 209–15. doi:10.1080/08916930802668610. PMID 19301202. S2CID 3135174.
  7. ^ Liu C, Wei Y, Wang J, Pi L, Huang J, Wang P (Sep 2012). "Carbonic anhydrases III and IV autoantibodies in rheumatoid arthritis, systemic lupus erythematosus, diabetes, hypertensive renal disease, and heart failure". Clinical and Developmental Immunology. 2012: 354594. doi:10.1155/2012/354594. PMC 3461255. PMID 23049597.
  8. ^ "Entrez Gene: CA3 carbonic anhydrase III, muscle specific".

Further reading

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[edit]
  • Overview of all the structural information available in the PDB for UniProt: P07451 (Carbonic anhydrase 3) at the PDBe-KB.