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3-Succinoylsemialdehyde-pyridine dehydrogenase

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3-Succinoylsemialdehyde-pyridine dehydrogenase
Identifiers
EC no.1.2.1.83
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

3-Succinoylsemialdehyde-pyridine dehydrogenase (EC 1.2.1.83) is an enzyme with systematic name 4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+

The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6.

References

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  1. ^ Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W (April 2012). "Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine". Applied and Environmental Microbiology. 78 (7): 2154–60. doi:10.1128/AEM.07025-11. PMC 3302611. PMID 22267672.
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